A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus

A Comparison of Four Treatments for Generalized Convulsive Status Epilepticus

A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.

BACKGROUND AND METHODS Although generalized convulsive status epilepticus is a life-threatening emergency, the best initial drug treatment is uncertain. We conducted a five-year randomized, double-blind, multicenter trial of four intravenous regimens: diazepam (0.15 mg per kilogram of body weight) followed by phenytoin (18 mg per kilogram), lorazepam (0.1 mg per kilogram), phenobarbital (15 mg ...

Current Treatment for Generalized Convulsive Status Epilepticus in Adults.

Status epilepticus (SE) is defined as a seizure lasting longer than 5 min, or at least two seizures without full recovery of consciousness between them. Early emergent medical management consists of life support and an etiology survey, and subsequent treatment can be classified into 4 stages: (1) early SE, (2) established SE, (3) refractory SE, and (4) super-refractory SE. For early SE, benzodi...

Non-convulsive status epilepticus.

The clinical, electrographic and reported neuropsychological features of 50 children with non-convulsive status epilepticus (NCSE) were reviewed and the children's progress followed for one to five years. NCSE occurred in a variety of epilepsies, especially the Lennox-Gastaut syndrome. Clinical manifestations ranged from obvious mental deterioration to subtle changes. The condition had often be...

Non-convulsive status epilepticus

Status epilepticus can complicate any type of seizure activity. A group of 13 children with non-convulsive status has been studied. Five presented with chronic fluctuating neurological features, while eight had intermittent episodes of their atypical status, although each of these lasted for several days. The clinical features, treatment, and outcome for these groups of children are described. ...